Although postoperative pelvic radiation and/or chemotherapy are often given, they have not been shown conclusively to increase survival. The most commonly used chemotherapeutic drugs include vincristine + Adriamycin or actinomycin-D + Cytoxan + DTIC .
Advanced leiomyosarcoma is treated with radiation therapy and/or chemotherapy.
Investigational
• Current studies include comparing postoperative pelvic radiation therapy versus no treatment, and
chemotherapy.
• Cisplatin has been shown not to be of benefit.
• For women with advanced disease, Adriamycin in combination with DTIC or Cytoxan has been shown to be
no more effective than Adriamycin alone.
• Vincristine has been used with actinomycin-D or Adriamycin and Cytoxan with or without DTIC with some
effectiveness in advanced disease.
• Mitoxantrone , a drug similar to Adriamycin, and ifosfamide are being studied.
